Oral potentially malignant disorders: Is malignant transformation predictable and preventable?

Oral potentially malignant disorders: Is malignant transformation predictable and preventable?

Leukoplakia is the most common potentially malignant disorder of the oral mucosa. The prevalence is approximately 1% while the annual malignant transformation ranges from 2% to 3%. At present, there are no reliable clinicopathological or molecular predicting factors of malignant transformation that can be used in an individual patient and such event can not truly be prevented. Furthermore, foll...

Oral Cancer and Oral Potentially Malignant Disorders

Predictive value of dysplasia grading and DNA ploidy in malignant transformation of oral potentially malignant disorders.

Dysplasia grading is widely used to assess risk of transformation in oral potentially malignant disorders despite limited data on predictive value. DNA ploidy analysis has been proposed as an alternative. This study examines the prognostic value for both tests used in a routine diagnostic setting to inform clinical management. A retrospective study of conventional dysplasia grading was conducte...

Malignant transformation in 5071 southern Taiwanese patients with potentially malignant oral mucosal disorders

BACKGROUND Oral cancers can be preceded by clinically evident oral potentially malignant disorders (OPMDs). The current study evaluated the rate and the time of malignant transformation in the various OPMDs in a cohort of patients from southern Taiwan. Parameters possibly indicative for malignant transformation of OPMDs, such as epidemiological and etiological factors, and clinical and histopat...

qat chewing and risk of potentially malignant and malignant oral disorders: a systematic review

background: qat (also known as khat , kat and miraa ) is a green-leaved plant ( catha edulis ). it is a shrub indigenous to yemen and certain parts of eastern africa. chewing the leaves, which have sympathomimetic and euphoric effects, has been documented in many countries and increased with worldwide migration. the effect of long-term chewing qat on the oral cavity is unknown. objective: a sys...